Breast cancer and melation



Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and breast cancer and melation A randomized study of low-dose subcutaneous interleukin-2 plus melatonin versus supportive care alone in metastatic colorectal cancer patients progressing under 5-fluorouracil and folates. In vivo studies Melatonin inhibited growth of HeLa cervical cancer xenografts perfused in situ in nude rats, via inhibiting aerobic glycolysis Warburg effect and fatty acid metabolic signaling breast cancer and melation ]. A randomized, placebo-controlled trial of melatonin on breast cancer survivors: A molecular case-control study on the association of melatonin hormone and rs single nucleotide polymorphism in its receptor MTNR1B gene with breast cancer.



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Breast cancer and melation

Melatonin for the prevention and treatment of cancer

Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting Survivin and XIAP. The anticancer effect of melatonin has also been observed in melanoma. Judging from the available evidence, melatonin's effect was more significant when it was used as an adjuvant therapy than being used alone for lung cancer.

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A possible mechanism of melatonin's anti-aromatase effect was through inhibition on COX activity and expression [ 65 ]. In this case, the laboratory study in cell culture or on animal models might be more clear and direct to assess the anticancer effect of melatonin and investigate the possible mechanisms involved in this process. Moreover, mechanisms of action should be investigated further.

Breast cancer and melation
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